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崔 华  教授  博士生导师 

崔华,中国科学技术大学化学系教授。2000年入选中国科学院“引进海外杰出人才”, 2006年获国家自然科学基金委“国家杰出青年基金”,2012年获中国化学会“分析化学基础研究梁树权奖”(国内分析化学的最高奖项),2013年获“中国科学院第四届十大杰出妇女”称号,2015年获得中国化学会分析化学专业委员会“中国女分析化学家奖”。2015-2016年任国际生物发光与化学发光理事会成员。另外,目前还担任《Anal. Bioanal. Chem.Editor以及《ACS sensor》和《分析化学》等杂志编委。主要从事纳米化学发光及其在生物分析中的应用研究。近年来,作为项目负责人先后承担了国家自然基金委国家重大科研仪器研制项目“研究单纳米粒子催化反应的化学发光与光热多功能成像系统”和科技部国家重点研发计划纳米科技专项项目“无标记纳米化学发光新一代体外诊断技术及其在急性心肌梗死快速诊断中的应用”,取得一系列创新性成果。开拓了金属纳米化学发光与电化学发光新领域;发明了发光试剂功能化纳米材料的“直接合成法”,率先合成化学发光试剂/催化剂双功能化新型纳米材料,发现其具有优异的异相化学发光催化特性,发展了高灵敏度的化学发光分析新方法,并将其用于重大疾病相关分析物的检测。相关工作受到国际同行的重要关注,受邀在法国、瑞典召开的16th & 18th International Symposium on Bioluminescence & Chemiluminescence和在法国召开的2nd International Meeting on Electrogenerated Chemiluminescence作大会特邀报告。
 

 

研究方向

    主要从事纳米化学发光与电致化学发光及其在免疫分析和DNA分析中的应用研究。

 

教学实践

   目前主讲一门研究生课程,并与其他教授合讲两门本科生课程以及一门研究生课程: 
   

    仪器分析(本科生课程)
   
高等分析方法(本科生课程)
    分子光谱分析进展(研究生课程)
    当代分析科学(研究生课程)

 

主要学术成绩、创新点及其科学意义   

    发现电致化学发光的多通道发射现象及其对电极电位、电极材料和电极表面状态等的依赖性,开辟了电位分辨的电致化学发光这一新的研究领域,推动了电致化学发光的深入研究;率先将纳米修饰电极用于电致化学发光的研究,发现鲁米诺等传统电致化学发光体系在纳米修饰电极上具有优异的电致化学发光特性;发现金属纳米粒子可作为能量接受体、微尺度反应平台、还原剂、催化剂等参与液相化学发光反应,将液相化学发光反应的研究对象从分子、离子体系扩展到金属纳米体系,开发了一系列新的化学发光体系;率先开展了化学发光功能化的金属纳米材料的合成、化学发光特性及其在生物分析中的应用研究,发展了一系列新的、简单的一步合成法,将发光试剂在合成的过程中直接键合到纳米金属的表面,成功制备了鲁米诺等多种发光试剂功能化的金和银纳米新材料,发现其具有良好的化学发光活性,实现了发光分子的富集和信号的放大,在此基础上进一步构建了高灵敏的生物分析探针,发展了一系列基于化学发光功能化纳米探针的免疫分析和DNA分析新方法。这些研究开创了化学发光与电致化学发光新的研究领域,不仅对化学发光、电致化学发光和纳米科学的基础理论研究具有重要的意义,而且在分析化学、生命科学、环境科学领域具有广阔的应用前景。到目前为止,她所领导的课题组已在Anal. Chem.Chem. Eur. J J. Phys. Chem. B & C Chem. Comm. Biosens. Bioelectron.Analyst等国际重要化学期刊上发表SCI论文100多篇受到同行专家的高度关注  

 

代表性论文专著  查看实验室所有学术论文

1. Y.T Liu, W. S, Q. Li, J.N Shu, L.F. Gao, M.M Ma, W. Wang and H Cui* "Firefly-mimicking intensive and long-lasting chemiluminescence hydrogels". Nature Commun., 2017, 8:1003, DOI: 10.1038/s41467-017-01101-6.

2. W.J Kong, X.N Zhao, Q.J Zhu, L.F Gao, and H. Cui*. "Highly Chemiluminescent Magnetic Beads for Label-Free Sensing of 2,4,6-Trinitrotoluene". Anal. chem., 2017, 89 (13), pp 71457151.

3. Z.L. Han, F. Li, J.N. Shu, L.F. Gao, X.Y. Liu, and H. Cui*, "Acridinium Ester-Functionalized Carbon Nanomaterials: General Synthesis Strategy and Outstanding Chemiluminescence", ACS Appl. Mater. Inter., 2016, 7 (27), 17454-17460.

4. Q. Li, F. Li, W. Shen, X.Y. Liu, and H. Cui*, "Lucigenin/Co(tryptophan)2 complex bifunctionalized graphene oxide: facile synthesis and unique chemiluminescence", J. Mater. Chem. C., 2016, 4, 3477-3484.

5. G.X. Li, X.X. Yu, D.Q. Liu, X.Y. Liu, F. Li, and H. Cui*, "Label-Free Electro chemiluminescence Aptasensor for 2,4,6-Trinitrotoluene Based on Bilayer Structure of Luminescence Functionalized Graphene Hybrids", Anal. chem., 2015, 87, 10976-10981.

6. G.X. Li, X.X. Yu, D.Q. Liu, X.Y. Liu, F. Li, and H. Cui*, "Label-Free Electro chemiluminescence Aptasensor for 2,4,6-Trinitrotoluene Based on Bilayer Structure of Luminescence Functionalized Graphene Hybrids", Anal. chem., 2015, 87, 10976-10981.

7. J.N. Shu, W. Wang, and H. Cui*, "Direct electrochemiluminescence of gold nanoparticles bifunctionalized by luminol analoguemetal complexes in neutral and alkaline media", Chem. Commun., 2015, 51, 1136611369 (back cover).

8. H.L. Zhang, Z.L. Han, X. Wang, F. Li, H. Cui*, D. Yang, and Z.P. Bian, "Sensitive Immunosensor for N-Terminal Pro-brain Natriuretic Peptide Based on N-(Aminobutyl)-N-(ethylisoluminol)-Functionalized Gold Nanodots/Multiwalled Carbon Nanotube Electrochemiluminescence Nanointerface", ACS Appl. Mater. Inter., 2015, 7 (14), 7599-7604.

9. X.Y. Liu , Z.L. Han , F. Li , L.F. Gao , G.L. Liang , and H. Cui*, "Highly Chemiluminescent Graphene Oxide Hybrids Bifunctionalized by N-(aminobutyl)-N-(ethylisoluminol)/ Horseradish Peroxidase and Sensitive Sensing of Hydrogen Peroxide", ACS Appl. Mater. Inter., 2015, 7 (33), 18283-18291.

10. S.Y. Li , D.Y. Chen , Q.T. Zhou , W. Wang , L.F. Gao , J. Jiang , H.J. Liang , Y.Z. Liu , G.L. Liang , and H. Cui*, "A General Chemiluminescence Strategy for Measuring AptamerTarget Binding and Target Concentration", Anal. Chem., 2014, 86 (11), 55595566.

11. M.X. Liu, H.L. Zhang, J.N. Shu, X.Y Liu, F. Li, and H. Cui*, "Gold Nanoparticles Bifunctionalized by Chemiluminescence Reagent and Catalyst Metal Complexes: Synthesis and Unique Chemiluminescence Property", Anal. Chem., 2014, 86 (6), 28572861.

12. F. Li, Y.Q. Yu, Q. Li, M. Zhou, H. Cui*, "A Homogeneous Signal-On Strategy for the Detection of rpoB Genes of Mycobacterium tuberculosis Based on Electrochemiluminescent Graphene Oxide and Ferrocene Quenching", Anal. Chem., 2014, 86 (3), 1608-1613.

13. Y. He , X. He , X.Y. Liu , L.F. Gao , and H. Cui*, "Dynamically tunable chemiluminescence of luminol functionalized silver nanoparticles and its application to protein sensing arrays", Anal. Chem., 2014. 86 (24), 12166 - 12171.

14. H.L. Zhang and H. Cui*, "High-density assembly of chemiluminescence functionalized gold nanodots on multiwalled carbon nanotubes and their application as biosensing platforms", Nanoscale, 2014, 6(5), 2563 - 2566.

15. L.F. Gao, H.L. Zhang, H. Cui*, "A general strategy to prepare homogeneous and reagentless GO/lucigenin&enzyme biosensors for detection of small biomolecules", Biosens. Bioelectron., 2014, 57, 65-70.

16. Y. He, Y.T. Chen, C.Y. Li and H. Cui*"Molecular Encoder - Decoder Based on Assembly of Graphene with Dye-labeled DNA", Chem. Commun., 2014, 50, 7994-7997.

17. F. Li, Y.T. Liu, M. Zhuang, H.L. Zhang, H. Cui*, "Biothiols as chelators for preparation of N-(aminobutyl)-N-(ethylisoluminol)/Cu2+ complexes bifunctionalized gold nanoparticles and sensitive sensing of pyrophosphate ion", ACS Appl. Mater. Inter., 2014, 6, 18104-18111.

18. N. Li, D.Q. Liu, H. Cui*, "Metal-nanoparticle-involved chemiluminescence and its applications in bioassays", Anal. Bioanal. Chem., 2014, 406(23), 5561-5571.

19. Y. He, G.M. Huang, and H. Cui*, "Quenching the Chemiluminescence of Acridinium Ester by Graphene Oxide for Label-Free and Homogeneous DNA Detection", ACS Appl. Mater. Interfaces, 2013, 5 (21), 1133611340.

20. Y. He, H. Cui*, "Chemiluminescent Logic Gates Based on Functionalized Gold Nanoparticles/Graphene Oxide Nanocomposites", Chemistry - A European Journal, 2013, 19(40), 1358413589.

21. F. Li, H. Cui*, "A label-free electrochemiluminescence aptasensor for thrombin based on novel assembly strategy of oligonucleotide and luminol functionalized gold nanoparticles", Biosens. Bioelectron., 2013, 39, 261-267.

22. Y.Q. Yu, Q. Cao, M. Zhou, H. Cui*, "A novel homogeneous label-free aptasensor for 2,4,6-trinitrotoluene detection based on an assembly strategy of electrochemiluminescent graphene oxide with gold nanoparticles and aptamer", Biosens. Bioelectron., 2013, 43. 137142.

23. Y. He, H. Cui*, "Label free and homogeneous histone sensing based on chemiluminescence resonance energy transfer between lucigenin and gold nanoparticles", Biosens. Bioelectron., 2013, (47), 313-317

24.  Y. He, G.M. Huang, J. Jiang, Q. Zhang, H. Cui*, "Preparation and electrochemiluminescent and photoluminescent properties of a graphene oxide colloid", Carbon., 2013, (56), 201-207.

25. D.Q. Liu, G.M. Huang, Y.Q. Yu, Y. He, H.L. Zhang and H. Cui*, "N-(Aminobutyl)-N-(ethylisoluminol) and hemin dual-functionalized graphene hybrids with high chemiluminescence", Chem. Commun., 2013, 49, 9794-9796.

26. Y. He, H. Cui**, Synthesis of Dendritic Platinum Nanoparticles/Lucigenin/Reduced Graphene Oxide Hybrid with Chemiluminescence Activity, Chem. Eur. J., 2012, 18, 4823-4826.

27. Y. He, H. Cui*, Synthesis of highly chemiluminescent graphene oxide/silver nanoparticle nano-composites and their analytical applications, J. Mater. Chem., 2012, 22, 9086-9091.

28. W. Shen, Y.Q. Yu, J.N. Shu, H. Cui*, A graphene-based composite material noncovalently functionalized with a chemiluminescence reagent: synthesis and intrinsic chemiluminescence activity, Chem. Commun., 2012, 48, 2894-2896.

29. Y. He, H. Cui*, Fabrication of Luminol and Lucigenin Bifunctionalized Gold Nnanoparticles/Graphene Oxide Nanocomposites with Dual-Wavelength Chemiluminescence, J. Phys. Chem. C, 2012, 116, 12593-12597.

30. Y.Q. Yu, M. Zhou, W. Shen, H.L. Zhang, Q. Cao, H. Cui*, Synthesis of electrochemiluminescent graphene oxide functionalized with a ruthenium(II) complex and its use in the detection of tripropylamine, Carbon, 2012, 50, 2539-2545.

31. W. Shen, D.Y. Tian, H. Cui*, D. Yang, Z.P. Bian, Nanoparticle-based electrochemiluminescence immunosensor with enhanced sensitivity for cardiac troponin I using N-(aminobutyl)-N-(ethylisoluminol)-functionalized gold nanoparticles as labels, Biosens. Bioelectron., 2011, 27, 18-24.

32. D.Y. Tian, Y. Chai, H.L. Zhang, H. Cui*, Synthesis of N-(aminobutyl)-N-(ethylisoluminol) functionalized gold nanomaterials for chemiluminescent bio-probe, Chem. Commun., 2011, 47, 4959-4961.

33. Y. He, D.Q. Liu, X.Y. He, H. Cui*, One-pot synthesis of luminol functionalized silver nanoparticles with chemiluminescence activity for ultrasensitive DNA sensing, Chem. Commun., 2011, 47, 10692-10694.

34. Y.Q. Yu, M. Zhou, H. Cui*, Synthesis and electrochemiluminescence of bis(2,2'- bipyridine)(5-amino-1,10-phenanthroline) ruthenium(II)-functionalized gold nanoparticles, J. Mater. Chem., 2011, 21, 12622-12625.

35. D.Y. Tian, C.F. Duan, W. Wang, H. Cui*, "Ultrasensitive electrochemiluminescence immunosensor based on luminol functionalized gold nanoparticle labeling", Biosens. Bioelectron., 2010, 25, 2290-2295.

36. N. Li, W. Wang, D.Y. Tian, H. Cui*, pH-dependent catalytic properties of PdAg nanoparticles in luminol chemiluminescence, Chem. Commun., 2010, 46, 1520-1522.

37. Y. Chai, D.Y. Tian, W. Wang, H. Cui*, A novel electrochemiluminescence strategy for ultrasensitive DNA assay using luminol functionalized gold nanoparticles multi-labeling and amplification of gold nanoparticles and biotin-streptavidin system, Chem. Commun., 2010, 46, 7560-7562.

38. C.F. Duan, H. Cui*, Time-tunable autocatalytic lucigenin chemiluminescence initiated by platinum nanoparticles and ethanol, Chem. Commun., 2009, 18, 2574-2576.

39. H. Zhang, H. Cui*, "Synthesis and Characterization of Functionalized Ionic Liquid-Stabilized Metal (Gold and Platinum) Nanoparticles and Metal Nanoparticle/Carbon Nanotube Hybrids", Langmuir, 2009, 25, 2604-2612.

40. H. Cui*, J.Z. Guo, N. Li, L.J. Liu, "Gold nanoparticle triggered chemilumineseence between luminol and AgNO3", J. Phys. Chem. C, 2008, 112, 11319-11323.

41. W. Wang, T. Xiong, H. Cui*, "Fluorescence and electrochemiluminescence of luminol-reduced gold nanoparticles: Photostability and platform effect", Langmuir, 2008, 24(6):2826-2833.

42. W. Wang, X. Yang, H. Cui*, "Growth mechanism of flowerlike gold nanostructures: surface plasmon resonance (SPR) and resonance rayleigh scattering (RRS) approaches to growth monitoring", J. Phys. Chem. C, 2008, 112, 16348-16353.

43. Y.P. Dong, H. Cui*, Y. Xu, "Comparative studies on electrogenerated chemiluminescence of luminol on gold nanoparticle modified electrodes", Langmuir, 2007, 23(2), 523-529.

44. H. Cui*, W. Wang, C.F. Duan, Y.P. Dong, J.Z. Guo, "Synthesis, characterization, and electrochemiluminescence of luminol-reduced gold nanoparticles and their application in a hydrogen peroxide sensor", Chem. Eur. J., 2007, 13 (24): 6975-6984.

45. Z.F. Zhang, H. Cui*, M.J. Shi, "Chemiluminescence accompanied by the reaction of gold nanoparticles with potassium permanganate", Phys. Chem. Chem. Phys., 2006, 8(8), 1017-1021.

46. H. Cui*, Z.F. Zhang, M.J. Shi, Y. Xu, Y.L. Wu, "Light Emission of Gold Nanoparticles Induced by the Reaction of Bis(2,4,6-trichlorophenyl) Oxalate and Hydrogen Peroxide", Anal. Chem., 2005, 77(19), 6402-6406.

47. H. Cui*, Z.F. Zhang, M.J. Shi, Chemiluminescent Reactions Induced by Gold Nanoparticles, J. Phys. Chem. B, 2005, 109, 3099-3103.

48. Z.F. Zhang, H. Cui*, C.Z. Lai, L.J. Liu, Gold nanoparticles-catalyzed luminol chemiluminescence and its analytical applications, Anal. Chem., 2005, 77(10), 3324-3329.

49. Q.L. Zhang, H. Cui*, A. Myint, M. Lian, L.J. Liu, "Sensitive determination of phenolic compounds using high-performance liquid chromatography with cerium(IV)-rhodamine 6G-phenolic compound chemiluminescence detection", J. Chromatogr. A, 2005, 1095(1-2), 94-101.

50. H. Xu, C.F. Duan, Z.F. Zhang, J.Y. Chen, C.Z. Lai, M. Lian, L.J. Liu, H. Cui*, Flow injection determination of p-aminophenol at trace level using inhibited luminol-dimethylsulfoxide-NaOH-EDTA chemiluminescence, Water Res., 2005, 39(23), 396-402.

51. H. Cui*, Y. Xu, Z.F. Zhang, Multi-channel electrochemiluminescence of luminol in neutral and alkaline aqueous solutions on a gold nanoparticles self-assembled electrodeAnal. Chem., 2004, 76, 13, 4002-4010.

52. H. Cui*, Y. Xu, Z.F. Zhang, Multi-channel electrochemiluminescence of luminol in neutral and alkaline aqueous solutions on a gold nanoparticles self-assembled electrodeAnal. Chem., 2004, 76, 13, 4002-4010.

53. H. Cui*, G.Z. Zou, X.Q. Lin, Electrochemiluminescence of luminol in alkaline solution at a paraffin-impregnated graphite electrode, Anal. Chem., 2003, 75, 324-331.

54. C.G. Xie, H. Cui*, Detection of tannic acid at trace level in industrial wastewaters using a highly sensitive chemiluminescence methodWater Res., 2003, 37, 233-237.

55. H. Cui, H.M. Hwang*, K, Zeng, H. Glover, H.T. Yu, Y.M. Liu, Riboflavin-photosensitized degradation of atrazine in a freshwater environmentChemosphere, 2002, 47, 991-999.

56. H. Cui*, C.X. He, and G.W. Zhao, Determination of polyphenols by high-performance liquid chromatography with inhibited chemiluminescence detection, J. Chromatogr. A, 1999, 855(1), 171-179.

57. H. Cui, L.E. Reusaet and A. Bult*, The precolumn fluorescent derivatization of antagonist [Arg6, D-Trp7,9, MePhe8]- substance P {6-11} with benzoin in HPLC and selective determination of arginine - containing fragments in its degradation products, J. Chromatogr. A, 1996, 736, 91-96.

58. H. Cui, L.E. Reusaet and A. Bult*, Selective determination of peptides containing specific amino acid residues in high performance liquid chromatography and capillary electrophoresis, J. Chromatogr. A, 1995, 704, 27-36.

注:未经特别说明,本页所有数据及相关信息统计于201711月。